A case of cyclic neutropenia in adults.
نویسندگان
چکیده
A 22 years old patient presented with recurrent episodes of diarrhoea, pharyngitis, apthous ulcers and fever for the past 6 months. The episodes lasted a week each time. The patient was admitted and blood studies revealed neutropenia with increased number of Large Granular Lymphocytes. Later on it was found out that his neutrophil count dropped to less than 0.2 x 10(9)/L after every 3 weeks. Bone marrow study revealed decreases neutrophil precursors during these episodes. He was diagnosed with adult onset cyclic neutropenia and his episodes were treated with G-CSF and Ceftriaxone.
منابع مشابه
Adult-onset cyclic neutropenia is associated with increased large granular lymphocytes.
Human cyclic neutropenia occurs in adults as well as children. Clinical illness is similar in the childhood and adult diseases, but distinctly different modes of onset suggest heterogeneity in its pathophysiology. We studied seven patients with cyclic neutropenia, three with disease acquired in adulthood, and four with the childhood-onset disorder. All three patients with adult-onset cyclic neu...
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Human cyclic neutropenia occurs in children and adults. Adult-onset cyclic neutropenia is an acquired disease characterized by increased numbers of large granular lymphocytes (LGL), in contrast to childhood-onset cyclic neutropenia in which LGL counts are normal. We investigated the clonality of lymphocytes in these two groups of patients by assessing the rearrangement status of the T cell rece...
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Detailed studies of patients with so called cyclic neutropenia has revealed involvement of monocytes, lymphocytes, reticulocytes and platelets as well(2). Hence the term cyclic hematopoiesis is more appropriate. These parameters have not been mentioned in the. reported case. There is also no mention of whether the child had organomegaly. This is relevant because patients with cyclic neutropenia...
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ورودعنوان ژورنال:
- JPMA. The Journal of the Pakistan Medical Association
دوره 62 3 شماره
صفحات -
تاریخ انتشار 2012